霍亂菌素;霍亂毒素

價格：面議
點(diǎn)擊數(shù)：435

產(chǎn)品介紹

中文名稱霍亂菌素;霍亂毒素

英文名稱 Cholera toxin from Vibrio cholerae；Choleragen；Choleragenoid

CAS識別號 9012-63-9

MDL識別號 Null,without related properties.

EC識別號 Null,without related properties.

Beilstein Null,without related properties.

分子式 Null,without related properties.

分子量 Null,without related properties.

分子結(jié)構(gòu)圖

產(chǎn)品性狀白色或淡黃色粉末。來源于霍亂弧菌，溶于水：10mg/ml
質(zhì)量標(biāo)準(zhǔn) 蛋白：~5% Lowry-TCA
活力：1×105～1×106 units protein
活力定義：One unit increases adenylate cyclase activity 6-fold, measured as [3H]-cAMP present, using approx. 70,000 CHO cells after incubation for 90 min at 37 °C with [3H]-adenine followed by a 15 min incubation with 1 mM 3-isobutyl-1-methylxanthine (IBMX).
Physical form：Lyophilized powder containing Tris buffer salts, sodium chloride, sodium azide and sodium EDTA。Toxin consisting of an A subunit (27 kDa) surrounded by five B subunits (approximately 12 kDa each), which attach the toxin to ganglioside GM1 on the cell surface. The A subunit catalyzes ADP-ribosylation of the α-subunit of the stimulatory G protein (Gαs), reducing GTPase activity and activating the α-subunit. This activation of Gαs leads to an increase in the activity of adenylyl cyclase, resulting in increased levels of cAMP. Also ADP-ribosylates transducin in the eye rod outer segments, inactivating its GTPase activity. Cholera toxin has also been reported to ADP-ribosylate tubulin. Shown to be a potent mucosal vaccine adjuvant, inducing T helper cell type 2 responses by inhibiting the production of interleukin-12.
儲存條件常溫密封避光保存，Stored in cool, dry and airproof.

【僅供科學(xué)研究使用】

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山東藍(lán)都生物科技有限公司

產(chǎn)品分類

霍亂菌素;霍亂毒素

產(chǎn)品介紹